BridgeBio Pharma, Inc.BBIO
NasdaqGS•Healthcare•Biotechnology
BridgeBio Pharma, Inc., a biopharmaceutical company, discovers, develops, and delivers medicines for patients with genetic diseases. The company offers Attruby, a next-generation oral small molecule near-complete TTR stabilizer for the treatment of cardiomyopathy of wild-type or transthyretin-mediated amyloidosis (ATTR-CM); Fosdenopterin, an intravenous formulation of synthetic cyclic pyranopterin monophosphate for the treatment of molybdenum cofactor deficiency under the NULIBRY brand name; and low-dose infigratinib, an oral FGFR1-3 selective tyrosine kinase inhibitor, which is in Phase 3 clinical stage or the treatment of children with achondroplasia and hypochondroplasia. It also develops Encaleret, an oral small molecule, negative allosteric modulator of the calcium sensing receptor, which is in phase 3 clinical study for the treatment of Autosomal Dominant Hypocalcemia Type 1(ADH1) and Chronic Hypoparathyroidism (CHP); BBP-418, an investigational, orally administered, and small molecule therapy that is in phase 3 clinical study for the treatment of LGMD2I; and BBP-812, an investigational adeno-associated virus (AAV) gene therapy for Canavan disease. In addition, the company engages in developing products for mendelian, oncology, and gene therapy diseases. It has license and collaboration agreements with the Bayer Consumer Care AG, Alexion Pharma International Operations Limited Company, Leland Stanford Junior University, and Novartis International Pharmaceutical Ltd. BridgeBio Pharma, Inc. was founded in 2015 and is headquartered in Palo Alto, California.
BridgeBio Pharma, Inc. (BBIO) reported trailing twelve months revenue of $579.96M as of March 2026, a 355.2% increase year-over-year. Quarterly revenue reached $194.51M, reflecting continued top-line momentum.
BridgeBio Pharma, Inc. reported a TTM net loss of $729.88M, with quarterly EBITDA of $-104.77M. The operating margin expanded from -89.5% to -54.5%, suggesting improving cost efficiency and pricing discipline.
The spread between operating margin (-54.5%) and net margin (-85.6%) indicates significant non-operating expenses or interest burden. Net margin has improved from -145.4% a year ago, signaling stronger bottom-line efficiency.
BBIO trades at a P/S of 23.3x.
The company reported negative free cash flow of $-197.35M, indicating cash consumption over the period. The balance sheet shows $1.37B in total assets with $2.65B in long-term debt against $-2.27B in stockholders equity. Data based on the most recent quarterly reports.
Competitive analysis based on 21 quarters of fundamental data
Operating margins are under pressure, averaging -2429.3%. The business may lack pricing power or face rising costs.'
Limited ROE data for a reliable assessment.
Only 1 of the last 8 quarters had positive FCF — the business may require external capital to sustain operations.
Revenue shows resilience with 5 of 7 quarters posting growth — demand is generally stable but has seen some soft patches.
Data-driven red flags and warnings across 21 quarters
The company posted negative operating margins in recent quarters — core operations are unprofitable.
Free cash flow has been negative in 7 of the last 8 quarters — earnings are not translating to cash.
Limited debt-to-equity data available.
Revenue is stable or growing over recent quarters — demand appears durable.
The last 7 consecutive quarters had negative FCF — the company is burning cash and may need external funding.
Shares outstanding rose 3.8% — mild dilution. Compare to earnings growth to assess net per-share impact.