Ionis Pharmaceuticals (IONS) Financial Metrics 2020-2026

Key metrics and charts across all fundamental categories.

Prices

Stock price and market valuation

Stock Price: $81.80
Market Cap: $13.49B

IONS trades at $81.8, a 171.1% increase year-over-year. Market capitalization stands at $13.49B, up 181.6% from the prior year. Track IONS price trends and market cap history to understand how the market values this company over time.

Stock Price

How the market values the company over time

Market Cap

Total equity value as determined by the market

Revenue & Profit

Revenue, EBITDA, operating income, net income, EPS, and shares across quarters

TTM Revenue: $1.06B
Q. Revenue: $246.09M
TTM EBITDA: $-335.43M
TTM Op. Income: $-352.25M
Q. Op. Income: $-117.42M
TTM Net Income: $-326.98M
Q. Net Income: $-92.53M
EPS: $-0.56
Shares Out.: $164.87M

$1.06B in TTM revenue grew 47.5% YoY, reaching $246.09M last quarter. TTM EBITDA of $-335.43M and TTM operating income of $-352.25M shows growth is flowing through. However, net income is negative at $326.98M — growth is not yet reaching the bottom line. Revenue is growing at a healthy pace — a signal to hold.

TTM Revenue

Reveals whether the core business is growing or shrinking

Quarterly Revenue

Highlights seasonal patterns and short-term momentum

TTM EBITDA

Shows if underlying operating profitability is improving

Quarterly EBITDA

Tracks near-term operating profitability trends

TTM Operating Income

Smoothed operating profit over the past four quarters

Quarterly Operating Income

Profit from core operations before financing costs

TTM Net Income

The bottom line — is the company making more money?

Quarterly Net Income

Short-term profit after all expenses and taxes

EPS

Earnings per share — profit attributable to each share

Shares Outstanding

Declining means buybacks benefit remaining holders

Assets & Liabilities

Assets, cash, debt, book value, and leverage

Total Assets: $3.45B
Cash: $173.38M
Long-Term Debt: N/A
Book Value: $491.41M
D/E Ratio: N/A
Debt/EBITDA: N/A

Total Assets

Expanding asset base can indicate business growth

Cash & Equivalents

Shows liquidity available for opportunities or downturns

Long-Term Debt

Declining debt trend is generally positive

Book Value (Equity)

Growing book value signals intrinsic value creation

Debt / Equity

Lower means less reliance on borrowed money

Debt / EBITDA

Below 2x is conservative; above 4x is high

Cash Flow

Operating cash flow, free cash flow, FCF margin, and earnings quality

Op. Cash Flow: $-792.82M
Free Cash Flow: $-814.58M
FCF Margin: -77.0%
FCF / Net Income: 8.8

FCF of $-814.58M on $-792.82M in operating cash flow. The FCF / Net Income ratio of 2.5x means earnings are well backed by actual cash — high-quality earnings.

Operating Cash Flow

Cash generated from core business operations

Free Cash Flow

Cash the business generates after maintaining itself

FCF Margin (%)

10%+ signals a capital-efficient business model

FCF / Net Income

Above 1 means earnings are backed by real cash

Margins

Profit margins across the income statement

Gross Margin: 98.8%
EBITDA Margin: -46.4%
Op. Margin: -47.7%
Net Margin: -37.6%

Op. margin of -47.7% is up 63.9% YoY — cost efficiency is improving. Net margin at -37.6% and gross margin of 98.8% — earnings take a bigger bite when COGS stays lean..

Gross Margin (%)

Revenue left after direct cost of goods sold

EBITDA Margin (%)

Operating profitability independent of capital structure

Operating & Net Margins (%)

How much of each dollar becomes profit

Price Ratios

Valuation multiples — is the company cheap or expensive?

P/E Ratio: N/A
P/S Ratio: 12.7x
P/B Ratio: 27.4x

P/S of 12.7x and P/B of 27.4x. A high P/S suggests growth expectations are priced in.

P/E Ratio

Higher suggests growth expectations; lower may signal undervaluation

P/S Ratio

Useful when earnings are volatile or negative

P/B Ratio

Below 1 means trading below accounting book value

EV / EBITDA

Lower multiple often signals better value

FCF Yield (%)

Cash return at current price — compare to bond yields

Earnings Yield (%)

Earnings return at current price — inverse of P/E

Others

Return ratios, efficiency, and credit metrics

ROE: -66.5%
ROA: -9.5%
Asset Turnover: 0.3
Rev/Share: $6.42

ROA of -9.5% shows how efficiently management uses assets to generate profit. Revenue per share at $6.418 removes dilution effects from top-line growth.

Return on Equity (ROE)

15%+ consistently signals a durable competitive advantage

Return on Assets (ROA)

How well management uses assets to generate profit

Asset Turnover

How efficiently assets generate each dollar of sales

Revenue per Share

Per-share revenue growth adjusted for dilution

Interest Coverage

How comfortably the company covers interest payments