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Ascendis Pharma A/S (ASND) Stock Fundamentals, Analysis & Risk Signals

Health score, competitive moat, risk signals, and key metrics at a glance.

NasdaqGS•Healthcare•Biotechnology
B
GoodMetricSide Score: 68/100
ProfitabilityProfit25/30
GrowthGrowth23/25
Balance SheetBalance18/25
Cash QualityCash2/20
Price & Volume

Ascendis Pharma A/S, operates as a biopharmaceutical company that focuses on developing TransCon-based therapies for unmet medical needs in Europe, the United States, and internationally. The company offers SKYTROFA for treating pediatric patients with growth hormone deficiency; and YORVIPATH, a once-daily subcutaneous injection for the treatment of adults with chronic hypoparathyroidism. It is also developing a pipeline of three independent endocrinology rare disease product candidates in clinical development, as well as focuses on advancing oncology therapeutic candidates. The company was incorporated in 2006 and is based in Hellerup, Denmark.

Moat Signals

Competitive analysis based on 53 quarters of fundamental data

Pricing Power

Weak Moat

Operating margins are under pressure, averaging -81.8%. The business may lack pricing power or face rising costs.'

Competitive Advantage

Moderate Moat

Limited ROE data for a reliable assessment.

Cash Generation

Weak Moat

Only 2 of the last 8 quarters had positive FCF — the business may require external capital to sustain operations.

Demand Durability

Strong Moat

TTM revenue has grown consistently (7 of 7 quarters up), with ~173.1% growth over the period. Strong demand durability.

Risk Signals

Data-driven red flags and warnings across 53 quarters

High Risk

Margin Pressure

Red Flag

The company posted negative operating margins in recent quarters — core operations are unprofitable.

Earnings Quality

Red Flag

Free cash flow has been negative in 6 of the last 8 quarters — earnings are not translating to cash.

Leverage Risk

Healthy

Limited debt-to-equity data available.

Revenue Decline

Healthy

Revenue is stable or growing over recent quarters — demand appears durable.

Cash Burn

Red Flag

The last 5 consecutive quarters had negative FCF — the company is burning cash and may need external funding.

Share Dilution

Red Flag

Shares outstanding increased 12.5% — significant dilution, likely from stock compensation or capital raises.

Metrics at a Glance

as of March 2026

Revenue & Profit

Revenue, EBITDA, operating income, net income, EPS, and shares

TTM Revenue
$867.51M
135.3%
Q. Revenue
$250.66M
TTM EBITDA
$-6.94M
97.1%
TTM Op. Income
$-6.93M
97.9%
Q. Op. Income
$25.22M
TTM Net Income
$506.60M
248.3%
Q. Net Income
$639.69M
EPS
N/A
Shares Out.
$64.52M
7.5%
$867.51M in TTM revenue grew 135.3% YoY, reaching $250.66M last quarter. TTM EBITDA of $-6.94M and TTM operating income of $-6.93M shows growth is flowing through. Net income of $506.60M TTM confirms the company is converting revenue into profit. Revenue is growing at a healthy pace — a signal to hold.

Margins

Gross, EBITDA, operating, and net margin trends

EBITDA Margin
11.8%
Op. Margin
10.1%
109.7%
Net Margin
255.2%
372.3%
Op. margin of 10.1% is up 113.3% YoY — cost efficiency is improving. Net margin at 255.2%.

Price Ratios

P/E, P/S, P/B, EV/EBITDA, FCF yield, and earnings yield

P/E Ratio
27.8x
P/S Ratio
16.2x
P/B Ratio
28.8x
At 27.8x P/E, the stock trades in line with market averages — fairly valued. P/S of 16.2x and P/B of 28.8x provide additional context. Assess whether the current multiple is justified by the company's growth and profitability trajectory.

Assets & Liabilities

Total assets, cash, debt, book value, and leverage

Total Assets
$2.01B
Cash
$573.42M
Long-Term Debt
$386.11M
Book Value
$488.48M
D/E Ratio
0.8
Debt/EBITDA
13.1
With $2.01B in assets and $386.11M in long-term debt, the D/E of 0.8and book value of $488.48M — shows a conservative capital structure — the company has a strong financial cushion to weather downturns.

Cash Flow

Operating cash flow, free cash flow, FCF margin, and earnings quality

Free Cash Flow
$-15.69M
4.5%
FCF Margin
-1.8%
FCF / Net Income
-0.0
FCF of $-15.69M. The FCF / Net Income ratio of -0.0x shows cash consumption — the business is not yet self-funding.

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