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Kiniksa Pharmaceuticals Interna (KNSA) Stock Fundamentals, Analysis & Risk Signals

Health score, competitive moat, risk signals, and key metrics at a glance.

NasdaqGS•Healthcare•Drug Manufacturers - Specialty & Generic
A
ExcellentMetricSide Score: 80/100
ProfitabilityProfit20/30
GrowthGrowth23/25
Balance SheetBalance17/25
Cash QualityCash20/20
Price & Volume
Market Cap $4.66B

Kiniksa Pharmaceuticals International, plc, a biopharmaceutical company, develops and commercializes medical therapies in the United States, the United Kingdom, and internationally. The company offers ARCALYST, an interleukin-1alpha and 1beta cytokine trap for the treatment of recurrent pericarditis, a chronic autoinflammatory cardiovascular disease and cardiac sarcoidosis. It also develops KPL-387, an investigational and fully human immunoglobulin G2 monoclonal antibody, which is Phase 2/3 clinical trial for the treatment of recurrent pericarditis; and KPL-116, a Fc-modified immunoglobulin G2 monoclonal antibody, which is in pre-clinical stage. The company was formerly known as Kiniksa Pharmaceuticals, Ltd. and changed its name to Kiniksa Pharmaceuticals International, plc in June 2024. Kiniksa Pharmaceuticals International, plc was incorporated in 2015 and is based in London, the United Kingdom.

Moat Signals

Competitive analysis based on 32 quarters of fundamental data

Pricing Power

Weak Moat

Operating margins are under pressure, averaging 4.3%. The business may lack pricing power or face rising costs.'

Competitive Advantage

Weak Moat

ROE is low or negative, suggesting limited competitive advantage or capital allocation challenges.

Risk Signals

Data-driven red flags and warnings across 32 quarters

Some Concerns

Margin Pressure

Red Flag

The company posted negative operating margins in recent quarters — core operations are unprofitable.

Earnings Quality

Watch

FCF/Net Income has dropped below 0.7x in 3 quarters — monitor for earnings quality deterioration.

Leverage Risk

Healthy

Limited debt-to-equity data available.

Revenue Decline

Healthy

Revenue is stable or growing over recent quarters — demand appears durable.

Cash Burn

Healthy

Free cash flow is consistently positive — the business self-funds without external capital reliance.

Share Dilution

Red Flag

Shares outstanding increased 7.8% — significant dilution, likely from stock compensation or capital raises.

Metrics at a Glance

as of March 2026

Revenue & Profit

Revenue, EBITDA, operating income, net income, EPS, and shares

TTM Revenue
$754.04M
56.7%
Q. Revenue
$214.27M
TTM EBITDA
$93.22M
689.9%
TTM Op. Income
$93.22M
689.9%
Q. Op. Income
$29.27M
TTM Net Income
$73.06M
531.0%
Q. Net Income
$22.59M
EPS
$0.3
Shares Out.
$76.52M
5.3%
$754.04M in TTM revenue grew 56.7% YoY, reaching $214.27M last quarter. TTM EBITDA of $93.22M and TTM operating income of $93.22M shows growth is flowing through. Net income of $73.06M TTM confirms the company is converting revenue into profit. Revenue is growing at a healthy pace — a signal to hold.

Margins

Gross, EBITDA, operating, and net margin trends

Gross Margin
90.3%
3.7%
EBITDA Margin
13.7%
Op. Margin
13.7%
41.8%
Net Margin
10.5%
70.1%
Op. margin of 13.7% is up 4.0% YoY — cost efficiency is improving. Net margin at 10.5% and gross margin of 90.3% — earnings take a bigger bite when COGS stays lean..

Price Ratios

P/E, P/S, P/B, EV/EBITDA, FCF yield, and earnings yield

P/E Ratio
63.8x
P/S Ratio
6.2x
P/B Ratio
7.7x
At 63.8x P/E, the stock trades at a premium — the market expects above-average growth. P/S of 6.2x and P/B of 7.7x provide additional context. Assess whether the current multiple is justified by the company's growth and profitability trajectory.

Assets & Liabilities

Total assets, cash, debt, book value, and leverage

Total Assets
$825.28M
Cash
$189.95M
Long-Term Debt
N/A
Book Value
$605.69M
D/E Ratio
N/A
Debt/EBITDA
0.0

Cash Flow

Operating cash flow, free cash flow, FCF margin, and earnings quality

Op. Cash Flow
$50.20M
TTM Free Cash Flow
$164.23M
275.5%
FCF Margin
21.8%
FCF / Net Income
2.2
TTM FCF of $164.23M on $50.20M in operating cash flow. The FCF / Net Income ratio of 2.2x means earnings are well backed by actual cash — high-quality earnings.

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Cash Generation

Strong Moat

Free cash flow is consistently positive and growing — a hallmark of a capital-light business that can self-fund growth.

Demand Durability

Strong Moat

TTM revenue has grown consistently (7 of 7 quarters up), with ~122.5% growth over the period. Strong demand durability.