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BeOne Medicines (ONC) Stock Fundamentals, Analysis & Risk Signals

Health score, competitive moat, risk signals, and key metrics at a glance.

NasdaqGS•Healthcare•Biotechnology
A
ExcellentMetricSide Score: 80/100
ProfitabilityProfit25/30
GrowthGrowth23/25
Balance SheetBalance25/25
Cash QualityCash7/20
Price & Volume
Market Cap $429.35B

BeOne Medicines AG, an oncology company, engages in discovering and developing various treatments for cancer patients in the United States, China, Europe, and internationally. The company's commercial stage products include BRUKINSA, a small molecule inhibitor of Bruton's Tyrosine Kinase (BTK) for the treatment of various blood cancers; TEVIMBRA, an anti-PD-1 antibody immunotherapy for the treatment of various solid tumor and blood cancers; SYLVANT for the treatment of adult patients with multicentric castleman disease; BAITUOWEI for patients with BC in premenopausal and perimenopausal women, and cancer; and PARTRUVIX for the treatment of various solid tumors. Its clinical stage products comprise Sonrotoclax BGB-11417, a small molecule Bcl-2 inhibitor; BGB-16673, a BTK targeting chimeric degradation activation compound active against wild type and mutant BTK; BG-60366, an EGFR-targeted CDAC; BG-89894 (SYH2039), a MAT2A Inhibitor; BGB-58067, an MTA-Cooperative PRMT5 Inhibitor; BG-T187 and BG-C0902, an anti-EGFRxMET trispecific antibody; BGB-26808, a HPK-1 Inhibitor; BGB-C354, an anti-B7H3 ADC; Zanidatamab, a bispecific HER2-targeted antibody; BG-C137, an anti-FGFR2b ADC; BGB-53038, a Pan-KRAS Inhibitor; BGB-B2033, an anti-GPC3x4-1BB bispecific antibody; BGB-B3227, an anti-MUC1xCD16A bispecific antibody; BG-C477, an anti-CEAADC; BGB-43395, a CDK4 Inhibitor; BG-68501, a CDK2 Inhibitor; BG-C9074, an anti-B7H4 ADC; BGB-21447, a Bcl-2 Inhibitor; and BGB-45035, an IRAK4-targeted CDAC. It also has various preclinical programs. The company has agreements Amgen, BMS, Bio-Thera, EUSA Pharma, Luye Pharmaceutical, and Novartis. The company was formerly known as BeiGene, Ltd. and changed its name to BeOne Medicines AG in May 2025. BeOne Medicines AG was founded in 2010 and is based in Basel, Switzerland.

Moat Signals

Competitive analysis based on 41 quarters of fundamental data

Pricing Power

Weak Moat

Operating margins are under pressure, averaging 2.2%. The business may lack pricing power or face rising costs.'

Competitive Advantage

Weak Moat

ROE is low or negative, suggesting limited competitive advantage or capital allocation challenges.

Cash Generation

Moderate Moat

5 of the last 8 quarters generated positive FCF. The company generally funds itself but has occasional cash consumption quarters.

Demand Durability

Strong Moat

TTM revenue has grown consistently (7 of 7 quarters up), with ~85.3% growth over the period. Strong demand durability.

Risk Signals

Data-driven red flags and warnings across 41 quarters

High Risk

Margin Pressure

Red Flag

The company posted negative operating margins in recent quarters — core operations are unprofitable.

Earnings Quality

Watch

FCF/Net Income has dropped below 0.7x in 3 quarters — monitor for earnings quality deterioration.

Leverage Risk

Watch

Debt-to-equity has risen 304.7% recently — increasing financial risk even if the current ratio is manageable.

Revenue Decline

Healthy

Revenue is stable or growing over recent quarters — demand appears durable.

Cash Burn

Watch

FCF turned negative in 3 of the last 8 quarters — occasional cash consumption.

Share Dilution

Red Flag

Shares outstanding increased 6.0% — significant dilution, likely from stock compensation or capital raises.

Metrics at a Glance

as of March 2026

Revenue & Profit

Revenue, EBITDA, operating income, net income, EPS, and shares

TTM Revenue
$5.74B
37.4%
Q. Revenue
$1.51B
TTM EBITDA
$908.86M
4587.5%
TTM Op. Income
$685.94M
331.9%
Q. Op. Income
$249.90M
TTM Net Income
$513.02M
230.8%
Q. Net Income
$227.36M
EPS
$0.16
Shares Out.
$1.44B
3.8%
$5.74B in TTM revenue grew 37.4% YoY, reaching $1.51B last quarter. TTM EBITDA of $908.86M and TTM operating income of $685.94M shows growth is flowing through. Net income of $513.02M TTM confirms the company is converting revenue into profit. Revenue is growing at a healthy pace — a signal to hold.

Margins

Gross, EBITDA, operating, and net margin trends

Gross Margin
89.0%
4.4%
EBITDA Margin
19.2%
Op. Margin
16.5%
1561.7%
Net Margin
15.0%
13116.0%
Op. margin of 16.5% is up 15.5% YoY — cost efficiency is improving. Net margin at 15.0% and gross margin of 89.0% — earnings take a bigger bite when COGS stays lean..

Price Ratios

P/E, P/S, P/B, EV/EBITDA, FCF yield, and earnings yield

P/E Ratio
836.9x
P/S Ratio
74.8x
P/B Ratio
90.2x
At 836.9x P/E, the stock trades at a premium — the market expects above-average growth. P/S of 74.8x and P/B of 90.2x provide additional context. Assess whether the current multiple is justified by the company's growth and profitability trajectory.

Assets & Liabilities

Total assets, cash, debt, book value, and leverage

Total Assets
$8.55B
Cash
$4.79B
Long-Term Debt
$962.51M
Book Value
$4.76B
D/E Ratio
0.2
Debt/EBITDA
3.3
With $8.55B in assets and $962.51M in long-term debt, the D/E of 0.2and book value of $4.76B — shows a conservative capital structure — the company has a strong financial cushion to weather downturns.

Cash Flow

Operating cash flow, free cash flow, FCF margin, and earnings quality

Op. Cash Flow
$201.34M
Free Cash Flow
$160.55M
1402.6%
FCF Margin
2.8%
FCF / Net Income
0.7
FCF of $160.55M on $201.34M in operating cash flow. The FCF / Net Income ratio of 0.3x indicates partial cash conversion — earnings quality needs attention.

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